Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in depression.

Competitive Antagonists of Adenosine Deaminase versus Enzymatic Inhibitors: Complementary Approaches Targeting Dipeptidyl Peptidase 4 (DP IV) and their Relation to MERS-CoV Infection

Cite this article: Reinhold D, Kähne T, Brocke S (2016) Competitive Antagonists of Adenosine Deaminase versus Enzymatic Inhibitors: Complementary Approaches Targeting Dipeptidyl Peptidase 4 (DP IV) and their Relation to MERS-CoV Infection. Ann Clin Cytol Pathol 2(3): 1028. *Corresponding author Stefan Brocke, Department of Immunology, University of Connecticut Health Center, Farmington, CT 0603...

Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA

Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV (DPP-IV)/CD26 and Aminopeptidase N (APN)/CD13 are ubiquitous ecto-enzymes which can digest various substrates including some ...

Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26 Inaugural-Dissertation zur Erlangung des Doktorgrades

The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV

Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA-CD26 binding has been implicated in causing severe combined immunodeficiency due to ADA deficiency. Using hum...

Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase.

The importance of ADA (adenosine deaminase) in the immune system and the role of its interaction with an ADA-binding cell membrane protein dipeptidyl peptidase IV (DPPIV), identical to the activated immune cell antigen, CD26, has attracted the interest of researchers for many years. To investigate the specific properties in the structure-function relationship of the ADA/DPPIV-CD26 complex, its ...